Micro-scaled Biomedical Device Laboratory                          logo

Research

Research Area 1. Large Scale Cell Culture Platforms for BioManufacturing

Park's group has been developing cost-effective and reliable platforms to culture animal cells on a large scale for biopharmaceutic production and stem cell therapy.

Rolled scaffold (RS) is a fully engineered meta-material for high-density adherent culture of animal cells. Bioreactors based on RS can culture a large population of adherent cells reliably and efficiently.

Hollow microcarrier (HMC) is a microcarrier to culture stem cells in a stirred tank bioreactor. It is a hollow sphere and the cells grow on its inner surface, enabling robust expansion of shear-sensitive stem cells on a large scale.

    >> A. Yekrangsafakar, A. Acun, J. W. Choi, E. Song, P. Zorlutuna, and K. Park, "Hollow microcarriers for large-scale expansion of anchorage-dependent cells in a stirred bioreactor," Biotechnology and bioengineering, 115(7), 1717-1728, 2018.



Research Area 2. Biomechanical Characterization of Adherent Cellls

Mechanical properties of cells are being actively investigated to understand their physiological and pathological characteristics. Park's group is devloping on practical techniques to investigate mechanical properties of adherent cells with a focus on cancer diagnostics and mechanobiology.

An OptoMechanical platform isdeveloped, which optically measures the mechanical stiffness of single adherent cells by laser interferometry. This platform is highly innovative, in that it is non-contact and non-invasive.

    >> K. Park, A. Mehrnezhad, E. Corbin, and R. Bashir, "Optomechanical measurement of the stiffness of single adherent cells," Lab on a Chip, vol. 15, pp. 3460-3464, 2015
    >> A. Mehrnezhad and K. Park, "Multi-frequency optomechanical stiffness measurement of single adherent cells on a solid substrate with high throughput," Analytical Chemistry, 2017.


An Ultrathin Cantilever is developed to measure the cell traction force of cancer cells and to build a self-stabilizing swimming biorobot actuated by living heart muscle cells.

    >> M. Holley, A. YekrangSafakar, M. Maziveyi, S. K. Alahari, K. Park, "Measurement of cell traction force with a thin film PDMS cantilever," Biomedical Microdevices 19 (4), 97, 2017.
    >> M. Holley, N. Nagarajan, C. Danielson, P. Zorlutuna, and K. Park, "Cardiac Muscle Cell-based Actuator and Self-stabilizing Biorobot-Part 1," Journal of Visualized Experiments, 123,  e55642, 2017.N.
    >> Nagarajan, M. Holley, C. Danielson, K. Park, and P. Zorlutuna, "Cardiac Muscle Cell-based Actuator and Self-stabilizing Biorobot-Part 2," Journal of Visualized Experiments, 123,  e55643, 2017.
    >> M. Holley, N. Nagarjan, C. Danielson, P. Zorlutuna, and K. Park, "Development and characterization of muscle-based actuators for self-stabilizing swimming biorobots," Lab on a Chip, vol. 16, 3473, 2016 (featured as inside front cover).


Kidong Park, Ph.D., Micro-Biomedical Laboratory

Division of Electrical & Computer Engineering
Louisiana State University, Baton Rouge, LA 70803, USA

Provide Website Feedback – www.lsu.edu/feedback                   Accessibility Statement – www.lsu.edu/accessibility